Alcohols and polyols
- (1)
- (55)
- (347)
- (41)
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- (55)
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- (399)
- (6)
- (102)
- (22)
- (50)
- (31)
- (63)
- (13)
- (14)
- (1)
- (2)
- (1)
- (25)
- (6)
- (4)
- (1)
- (6)
- (1)
- (463)
- (9)
- (46)
- (10)
- (46)
- (6)
- (1)
- (6)
- (13)
- (148)
- (116)
- (8)
- (5)
- (1)
- (1)
- (1)
- (1)
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- (1)
- (1)
- (4)
- (7)
- (14)
- (2)
- (1)
- (6)
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- (1)
- (12)
- (21)
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- (2)
- (2)
- (2)
- (16)
- (2)
- (30)
- (1)
- (4)
- (1)
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- (1)
- (20)
- (10)
- (4)
- (15)
- (1)
- (4)
- (6)
- (2)
- (1)
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- (2)
- (2)
- (1)
- (4)
- (3)
- (1)
- (28)
- (29)
- (7)
- (3)
- (5)
- (1)
- (36)
- (5)
- (4)
- (2)
- (5)
- (4)
- (17)
- (15)
- (4)
- (5)
- (1)
- (2)
- (5)
- (1)
- (4)
- (37)
- (4)
- (2)
- (6)
- (8)
- (2)
- (2)
- (8)
- (7)
- (7)
- (2)
- (1)
- (1)
- (26)
- (1)
- (1)
- (1)
- (2)
- (1)
- (3)
- (4)
- (2)
- (1)
- (15)
- (12)
- (1)
- (3)
- (2)
- (7)
- (12)
- (1)
- (14)
- (24)
- (1)
- (8)
- (4)
- (1)
- (2)
- (1)
- (22)
- (2)
- (6)
- (5)
- (2)
- (1)
- (5)
- (3)
- (4)
- (24)
- (5)
- (3)
- (5)
- (14)
- (1)
- (1)
- (1)
- (11)
- (3)
- (2)
- (4)
- (11)
- (2)
- (6)
- (4)
- (1)
- (3)
- (6)
- (11)
- (5)
- (4)
- (1)
- (2)
- (11)
- (14)
- (7)
- (2)
- (3)
- (1)
- (3)
- (1)
- (2)
- (1)
- (10)
- (1)
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- (4)
- (1)
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- (1)
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- (1)
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- (30)
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Medchemexpress LLC CP-640186 (hydrochloride) | 591778-70-0 | C30H36ClN3O3 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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CP-640186 hydrochloride is an orally active and cell-permeable inhibitor of Acetyl-CoA carboxylase (ACC). It exhibits IC50 values of 53 nM for rat liver ACC1 and 61 nM for rat skeletal muscle ACC2. ACC is a crucial enzyme involved in fatty acid metabolism, responsible for synthesizing malonyl-CoA. This compound also promotes muscle fatty acid oxidation.
- Orally active and cell-permeable.
- Inhibits Acetyl-CoA carboxylase (ACC).
- IC50s: 53 nM for rat liver ACC1, 61 nM for rat skeletal muscle ACC2.
- Stimulates muscle fatty acid oxidation.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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![Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386677-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Aplaviroc hydrochloride, an SDP derivative, is a potent CCR5 antagonist. It exhibits strong activity against various HIV-1 strains, including wild-type and multidrug-resistant variants, by binding to CCR5 with high affinity and inhibiting gp120/CD4 binding. This compound has been shown to suppress R5 HIV-1 viremia in in vivo models.
- Potent activity against three wild-type R5 HIV-1 strains (HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW).
- Substantially more potent than previously published CCR5 inhibitors.
- Suppresses infectivity and replication of two HIV-1MDR variants.
- Binds to CCR5 with high affinity.
- Potently blocks rgp120/sCD4 binding to CCR5.
- Exerts potent anti-R5 human immunodeficiency virus type 1 effects in a novel AIDS mouse model.
- Suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Articaine (hydrochloride) | 23964-57-0 | 99.38% | 25 MG
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Articaine hydrochloride is a selective inhibitor of voltage-gated sodium channels (e.g., rNav1.4, hNav1.7, and rNav1.8). It exhibits local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction. Additionally, it can inhibit NF-κB activation and NLRP3 inflammasome pathways, demonstrating anti-inflammatory properties. This compound is suitable for studying dental local anesthesia and inflammatory-related diseases such as acute kidney injury.
- Selective inhibitor of voltage-gated sodium channels
- Exhibits local anesthetic activity by inhibiting Na+ influx
- Can inhibit NF-κB activation and NLRP3 inflammasome pathways
- Displays anti-inflammatory function
- Used in research for dental local anesthesia and inflammatory-related diseases
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Medchemexpress LLC Mefuparib hydrochloride | 1449746-00-2 | 98.6% | 334.77 | 5 MG
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Mefuparib hydrochloride is an orally active, substrate-competitive, and selective inhibitor of PARP1/2, with IC50 values of 3.2 nM and 1.9 nM respectively. It is known to induce apoptosis and exhibits significant anticancer activity both in vitro and in vivo.
- Orally active.
- Substrate-competitive and selective PARP1/2 inhibitor.
- Induces apoptosis.
- Possesses prominent anticancer activity in vitro and in vivo.
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Medchemexpress LLC PRT062607 Hydrochloride | 1370261-97-4 | 98.07% | 429.91 | 50 MG
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PRT062607 Hydrochloride is an orally available Syk inhibitor that effectively inhibits inflammation and induces apoptosis. It demonstrates potent antitumor activity in tumor xenograft mouse models. This compound inhibits phosphorylation of ERK, AKT, and SYK in Ramos cells, and BLNK Tyr84 phosphorylation in a concentration-dependent manner.
- Inhibits B cell antigen receptor-mediated B cell signaling and activation
- Inhibits Fc receptor 1-mediated induced basophil degranulation
- Produces dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
- Prevents BCR-induced splenomegaly in mice
- Prevents Ramos tumor formation in mouse xenograft models
- Significantly inhibits NHL tumor growth in xenograft models
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Medchemexpress LLC Asenapine hydrochloride (Org 5222 hydrochloride) | 1412458-61-7 | 99.95% | 322.23 | 50 MG
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Asenapine hydrochloride (Org 5222) is an atypical antipsychotic primarily investigated for its role in schizophrenia and bipolar disorder research. It acts as a potent antagonist across a diverse range of receptors, including serotonin, adrenoceptors, dopamine, and histamine.
- Exhibits higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B, and D3 receptors relative to its D2 receptor affinity.
- Potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8), and H1 (8.4) receptors.
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Medchemexpress LLC Nevanimibe hydrochloride | 133825-81-7 | MFCD00899568 | 99.5% | 458.08 g/mol | C27H40ClN3O | 1 ML
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Nevanimibe hydrochloride is the hydrochloride salt of nevanimibe, a selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor supplied as a 10 mM solution in DMSO (1 mL) for in vitro research use.
- Selective ACAT1 inhibitor with low-nanomolar activity
- Supplied as a ready-to-use 10 mM solution in DMSO
- High purity (~99.5%) suitable for biochemical and cell-based assays
- Molecular weight 458.08 g/mol aids solution preparation calculations
- Available in solid and solution formats for flexibility in workflows
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Medchemexpress LLC AMXI-5001 hydrochloride | 00-00-0 | 98.1% | C25H21ClFN5O3 | 10MG
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AMXI-5001 hydrochloride is a research-grade small molecule described as a dual inhibitor of PARP1/2 and microtubule polymerization. It shows potent cellular activity against PARP and tubulin targets, with reported favorable metabolic stability and oral bioavailability, and is intended for preclinical anticancer research.
- Dual mechanism: inhibits PARP1/2 and tubulin polymerization.
- Potent PARP inhibition with low nanomolar IC50s and tubulin inhibition in the micromolar range.
- Orally bioavailable with favorable pharmacokinetic properties.
- Suitable for in vitro and in vivo anticancer studies.
- High purity for research applications.
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Medchemexpress LLC Aprindine hydrochloride | 33237-74-0 | 98.96% | C22H31ClN2 | 1 ML
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Aprindine hydrochloride | 33237-74-0 | 98.96% | C22H31ClN2 | 1 ML
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Medchemexpress LLC OTS186935 hydrochloride | 99.6% | 522.31 | 50 MG
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OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. It significantly inhibits tumor growth in mouse xenograft models without detectable toxicity and regulates the production of γ-H2AX in cancer cells.
- Potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM.
- Shows significant inhibition of tumor growth in mouse xenograft models.
- Does not exhibit any detectable toxicity in mouse xenograft models.
- Regulates the production of γ-H2AX in cancer cells.
- Inhibits A549 cell growth with an IC50 of 0.67 μM.
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Medchemexpress LLC Slm6031434 hydrochloride | 1897379-34-8 | 99.1% | 1 MG
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A selective sphingosine kinase 2 (SphK2) inhibitor supplied as the hydrochloride salt for research use. Solid, high-purity material characterized by molecular formula C22H31ClF3N5O2 and molecular weight 489.96 Da.
- Selective sphingosine kinase 2 inhibitor for biochemical and cellular studies.
- Hydrochloride salt form, supplied as a solid powder.
- High purity (reported 99.1%), suitable for research applications.
- Soluble in water at approximately 40 mg/mL with ultrasonic warming if required.
- Recommended storage: long-term in solvent at -80°C, short-term at -20°C, sealed and away from moisture.
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Medchemexpress LLC Akalumine (hydrochloride) | 2558205-28-8 | 99.92% | 338.85 | 25 MG
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AkaLumine hydrochloride is a D-luciferin analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. It emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc, offering high tissue-penetration and increased detection sensitivity for deep-tissue targets. It is intended for research use only and not for sale to patients.
- D-luciferin analogue
- Km of 2.06 μM for recombinant firefly luciferase protein
- Emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc
- High tissue-penetration
- Increases detection sensitivity from deep-tissue targets
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Medchemexpress LLC Berubicin hydrochloride | 293736-67-1 | 95.1% | 670.10 | 1 MG
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Berubicin hydrochloride is an analog of Doxorubicin that can cross the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). This product exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. It can be used in the study of tumors related to the nervous system.
- Crosses the blood-brain barrier
- Inhibits P-gp and MRP1-mediated efflux
- Suppresses glioblastoma multiforme (GBM)
- Activates nuclear factor κB (NF-κB)
- Induces apoptosis in neuroblastoma cells
- More potent activity than Doxorubicin in activating NF-κB and inhibiting DNA synthesis
- Prolongs survival time in intracranial orthotopic glioma models in mice
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Medchemexpress LLC Ladostigil hydrochloride | 209394-18-3 | 99.9% | 308.80 g/mol | C16H21ClN2O2 | 50 MG
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Ladostigil hydrochloride is the hydrochloride salt of ladostigil, an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase. It exhibits neuroprotective, antioxidant, and anti-inflammatory properties and is used as a research reagent in studies of neurodegeneration, depression, and Alzheimer's disease.
- Dual cholinesterase and monoamine oxidase inhibitor
- Neuroprotective, antioxidant, and anti-inflammatory activity
- Hydrochloride salt for improved solubility
- Click-chemistry compatible (contains an alkyne group)
- High purity verified by RP-HPLC, suitable for research
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Medchemexpress LLC Etifoxine hydrochloride | 56776-32-0 | 99.8% | 337.24 | 10 MM 1 ML
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Etifoxine hydrochloride is a non-benzodiazepine GABAergic compound. It acts as a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. It has demonstrated anxiolytic and anticonvulsant properties in rodents.
- Acts as a positive allosteric modulator of GABAA receptors.
- Demonstrates anxiolytic properties.
- Demonstrates anticonvulsant properties.
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